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KMID : 1100220060050010029
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Dementia and Neurocognitive Disorders
2006 Volume.5 No. 1 p.29 ~ p.32
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Transient Hyperphagia and Disinhibited Behaviors in a Patient with the Left Paramedian Thalamic Infarction
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Park Key-Chung
Lee Sang-Bum
Yoon Sung-Sang
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Abstract
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The core behavioral abnormality of the paramedian thalamic infarct is a state of somnolence and abulia accompanied by amnesia, frontal brain syndrome. In addition to these findings, distractibility, hyperorality, socially inappropriate behavior, mood changes and sexual disinhibition have been reported in some case studies. However, mood change, disinhibited behavior and hyperphagia are rare manifestations in patients with unilateral and focal medial thalamic lesion. We describe a case showing transient compulsive eating and disinhibited behavior in a patient with left mediodorsal thalamic infarction. The clinical and single photon emission computed tomography (SPECT) findings suggest that her beha- vioral changes result from the disconnection of frontal subcortical circuits, namely of the orbitofrontal loops which is associated with mood dysregulation and socially inappropriate behavior, and of the dorsolateral prefrontal loops which mediate executive cognitive functions.
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KEYWORD
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Frontal lobe dysfunction, Hyperphagia and Disinhibited behavior, Paramedian thalamic infarction
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